sengoloa sa hae se shebana le lefats'e le khahlang la liphatsa tsa lefutso tsa temo, ho hlahloba kamoo lipatlisiso tsa morao-rao li sebelisang matla a liphatsa tsa lefutso ho matlafatsa matla a lijalo khahlanong le maemo a mocheso a feteletseng le likokoana-hloko tse senyang. Ho latela lintlha tsa morao-rao le lintlha tse tsoang mehloling ea mahlale, re utolla menyetla ea tsoelopele ea liphatsa tsa lefutso ho fetola maemo a temo le ho matlafatsa lihoai, litsebi tsa temo, lienjiniere tsa temo le beng ba mapolasi ka litharollo tse tšoarellang.
Ho feto-fetoha ho feteletseng ha mocheso le tlhaselo e sa khaotseng ea likokoana-hloko li baka mathata a maholo tlhahisong ea temo ea lefatše. Leha ho le joalo, tsoelo-pele ea morao tjena liphuputsong tsa liphatsa tsa lefutso e na le tšepiso ea ho hōlisa lijalo tse ka atlehang tlas’a maemo a mabe. Ho ea ka phuputso e totobalitsoeng ho Phys.org, bo-rasaense ba khethile liphatsa tsa lefutso tse nang le karolo ea bohlokoa ho fana ka mamello ho mocheso o feteletseng le litlhaselo tsa pathogenic.
Lipatlisiso tse entsoeng ke sehlopha sa litsebi tsa liphatsa tsa lefutso tse etelletsoeng pele ke Dr. Emily Watson ho tsoa Setsing sa Saense ea Lijalo Univesithing ea Temo e khethile mefuta e fapaneng ea liphatsa tsa lefutso e amanang le mamello e matlafalitsoeng ea mocheso o feteletseng. Ka ho hlahloba DNA ea mefuta e fapaneng ea lijalo, ho kenyeletsoa lijo-thollo tse tloaelehileng tse kang koro le raese, bafuputsi ba ile ba sibolla liphatsa tsa lefutso tse itseng tse thusang limela ho mamella mocheso o feteletseng le khatello ea maikutlo e batang. Mefuta ena ea liphatsa tsa lefutso e thusa ho kenya ts'ebetso ea mekhoa ea ts'ireletso, joalo ka liprotheine tsa mocheso oa mocheso le li-osmolyte, tse sireletsang limela liphellong tse senyang tsa mocheso o feteletseng.
Ho phaella tabeng ea ho mamella mocheso o feteletseng, bo-rasaense ba boetse ba sibolla litsela tsa lefutso tse matlafatsang khanyetso khahlanong le likokoana-hloko. Ka lithuto tse felletseng tsa liphatsa tsa lefutso, bafuputsi Setsing sa Temo sa Genomics ba khethile liphatsa tsa lefutso tsa bohlokoa tse nolofalletsang limela ho lemoha le ho arabela ka katleho litlhaselong tsa pathogenic. Liphatsa tsa lefutso tsena li kenyelletsa liprotheine tsa ho hanyetsa mafu, joalo ka liprotheine tsa NBS-LRR (nucleotide-binding site leucine-rich repeat) tse bapalang karolo ea bohlokoa ho qaleng karabelo ea 'mele ea ho itšireletsa mafung khahlanong le likokoana-hloko tse hlaselang. Ho utloisisa moralo oa lefutso oa ho hanyetsa maloetse ho fana ka monyetla oa ho jala lijalo tse nang le tšireletso e matla ho mafu a senyang a limela.
Ho kopanngoa ha liphatsa tsa lefutso mananeong a ho ikatisa ho se ho ntse ho fana ka liphello tse tšepisang. Ka ho sebelisa mekhoa e mecha ea liphatsa tsa lefutso, balemi ba limela ba ka tseba le ho khetha mefuta e nang le litšobotsi tse lakatsehang, e leng ho potlakisa nts'etsopele ea lijalo tse mamellang le tse behang haholo. Ho feta moo, mekhoa ea boenjineri ba liphatsa tsa lefutso, joalo ka ho hlophisa liphatsa tsa lefutso ho sebelisa theknoloji ea CRISPR-Cas9, e fana ka mekhoa ea ho hlahisa mefuta e itseng e molemo kapa ho fetola e seng e ntse e le teng ho matlafatsa mamello ea lijalo ho ea pele.
Litlamorao tsa ho sebelisa liphatsa tsa lefutso ho loantša mocheso o feteletseng le likokoana-hloko li tebile. Balemi ba ka lema lijalo tse hlomelloang hamolemonyana bakeng sa ho mamella mocheso o matla, komello le serame, ho fokotsa tahlehelo ea chai le ho netefatsa tšireletso ea lijo. Litsebi tsa temo le baenjiniere ba temo ba ka qapa mekhoa ea temo e tsitsitseng e lumellanang le matla a liphatsa tsa lefutso a lijalo tse mamellang, ho ntlafatsa tšebeliso ea lisebelisoa le ho fokotsa litlamorao tsa tikoloho. Ho feta moo, sechaba sa mahlale se ka tsoela pele ho hlahloba bokhoni bo boholo ba lipatlisiso tsa lefutso ho notlolla maano a macha a ntlafatso ea lijalo.
Qetellong, ho kopana ha liphatsa tsa lefutso le temo ho bula menyetla e thabisang ea ho hlōla mathata a bakoang ke mocheso o feteletseng le litšokelo tsa pathogenic. Ho tsebahatsa le ho sebelisoa ha liphatsa tsa lefutso tse amanang le mamello ho fana ka tsela e lebisang mekhoeng e tsitsitseng ea temo le ho eketsa tlhahiso ea lijalo. Ha re ntse re tsoela pele ho teba ka har'a sebopeho se rarahaneng sa liphatsa tsa lefutso tsa lijalo, bokamoso bo na le monyetla o moholo oa ho hlahisa litharollo tse ikhethileng ho rarolla litlhoko tse ntseng li tsoela pele tsa lihoai, litsebi tsa temo, lienjiniere tsa temo, beng ba mapolasi le bo-ramahlale ba sebetsang ka thata ho fepa lefatše.
Tags: temo, liphatsa tsa lefutso, ho mamella lijalo, mocheso o feteletseng, likokoana-hloko, boenjiniere ba liphatsa tsa lefutso, temo e tsitsitseng, ho ikatisa lijalo, mafu a limela